微波法合成乙酰苯胺

Synthesis of Acetanilide under Microwave Irradiation

报道了采用微波技术制备乙酰苯胺的方法,同时对影响收率诸因素进行考察,确定了最佳反应条件:微波辐射功率600W,苯胺与冰醋酸的摩尔比为1∶2.5,反应时间20min,乙酰苯胺的收率可达80.6%.与常规加热反应对比,发现采用微波辐射法缩短了反应时间,提高了反应速率和收率.

The use of microwave irradiation has attracted much attention in organic synthesis in recent decades.We have employed this method for the synthesis of acetanilide,giving 80.6% yields in 20 minutes.Compared with traditional methods,this new method has the advantages of less agent consumption and higher yields in a short time . 