MAPK的细胞内定位与激活后移位机制

Mechanisms of The Subcellular Localization and Stimuli-induced Translocation of MAP Kinases

信号蛋白的亚细胞定位和激活后移位已成为细胞信号转导研究中的重要内容 .MAPK信号通路是真核细胞中的重要信号转导系统 .MAPK在细胞中有着相对固定的定位 ,在适宜的刺激作用下会移位入核并产生相应的生理效应 .目前认为 ,MAPK的磷酸化状态及与其他蛋白质 ,如上游激酶、磷酸酶和下游底物之间的相互作用 ,可能在其特异性定位与激活后移位中起作用 .MAPK的定位与移位机制的阐明 。

The subcellular localization and translocation of signaling proteins have risen large interest in the study of cellular signal transduction. MAP kinase pathways are key signaling systems in eukaryotic cells. MAP kinases have relatively specific localization in cells, and translocate into nucleus upon appropriate stimuli, leading to consequent physiological effects. It has been shown that the phosphorylation state of MAPKs as well as the interactions between MAP kinases and other proteins such as the upstream kinases, phosphatases, and downstream substrates may play a role in their specific localization and translocation. The elucidation of the mechanisms of localization and translocation of MAP kinases will be helpful to understand their in vivo functions.