中心体异常和肿瘤

Centrosome Abnormality and Carcinogenesis

中心体是紧靠细胞核的小体积细胞器 ,由中心粒和中心粒外周基质 (PCM)组成 .中心体的蛋白质组成、形态、大小和位置随细胞周期不断发生变化 .中心体复制过程与细胞核内其他事件相耦合 ,并与DNA复制一样 ,以半保留方式复制 .现已发现了许多中心体蛋白及与中心体复制相关的蛋白激酶 ,调控着中心体复制的各个步骤 .中心体复制还受p5 3,Rb ,p2 1,Gadd4 5和Brca1/ 2等多个负性基因调节 ,中心体异常与基因组不稳定性存在相关性 。

Centrosome is a tiny organelle which consists of two barrel-shaped centrioles surrounded by a fibrous meshwork termed as the pericentriolar material (PCM). The composition, morphology, size and position of the centrosome in a cell changes continually with cell cycle progression. Duplication of the centrosome is semiconservative and is coordinated with other cell cycle events, including DNA synthesis. Many centrosome-related proteins and kinases have been found to regulate different steps of centrosome duplication. Many growth-suppression genes such as p53, Rb, p21, Gadd45 and Brca1/2 are also involved in control of the duplication process. Centrosome abnormalities are associated with genomic instability and may play important roles in development of human cancers.