期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

多药耐药基因的研究现况及应用

下载PDF
导出
摘要 肿瘤细胞对多种细胞毒药物的拮抗性是影响肿瘤化疗的主要障碍.它是以肿瘤细胞对亲脂性细胞毒药物,包括各种植物碱类抗肿瘤药物的交叉拮抗为特征,可分为天然性和获得性耐药,区别在于后者是在化疗过程中诱导的对一种抗肿瘤药物产生耐药后,同时对其他不相关非同类药物亦产生耐药性,即多耐药性(multidrug resistance,MDR).MDR的产生机制复杂,常见原因是P-糖蛋白(Pgp)的超表达.
作者 安立彬 谭岩 刘力华
机构地区 吉林大学第一医院中心实验室
出处 《中国生物制品学杂志》 CAS CSCD 2003年第5期316-319,共4页 Chinese Journal of Biologicals
关键词 多药耐药基因 肿瘤细胞 化疗 拮抗性
分类号 R730 [医药卫生—肿瘤]
  • 相关文献

参考文献23

  • 1Chen CJ,Pastan I,Gottesman MM,et al.Internal duplication and homology with bacterial transport proteins in the mdrl(P-glycoprotein) gene from multidrug-resistant human cells. Cell, 1986,47:381-389.
  • 2Zhou Y,Gottesman MM,Pastan I,et al. Studies of human MDR1-MDR2 chimeras demonstrate the functional exchangeability of a major transmembrane segment of the multidrug transporter and phosphatidylchoine flippase. Mol Cell Bid, 1999,19(2) : 1450-1459.
  • 3Schinkd AH, Mayer U, Wagmaar E, et al. Normal viability and altered pharmacokinetics in mice lacking mdrl-type P-glycoprotein. Proc Natl Acad Sci USA, 1997,94:4028-4033.
  • 4Maddden MJ,Morrow CS,Nakagawa M, et al. Identification of 5' and 3' sequences involved in the regulation of transcription of the human mdrl gene in vivo. J Bid Chem, 1993,268(1):8290-8297.
  • 5Hu Z, Jin SK, Kathleen W. Sotto, et al. Transcriptional activation of the MDR1 gene by UV irradiation. J Bid Chem, 2000,275(4):2979-2985.
  • 6Nuria E,Vilaboat,galan A,et al. Regulation of multidrug resistance 1(MDR1)/P-glycoprotein gene expression and activity by heat-shock transcription factor 1(HSF1).Biol Chem,2000,275(32): 24970-24976.
  • 7Stein U, Jurchott K, Walther W, et al. Hyperthermia-induced nuclear translocation of transcription factor YB-1 leads to enhanced espression of multidrug resietance-related ABC transporters.J Biol Chem,2001,276(30)28562-28569.
  • 8Dhir R, Buschman E, Gme P, et al. Structural and functional characterization of the mouse multidrug resistance gene family. Bull Cancer, 1990,77(11):1125-1129.
  • 9Currier SJ, Pastan I, Gotteman MM,et al. Identification of residues in the first cytoplamic loop of P-glycoprotein involved in the function of chimerie human MDRI-MDR2 transporters. J Biol Chem, 1992, 267 (35):25153-25159.
  • 10Ruth A, Wilfred D, Rose E,et al. Coordinate changes in drug resistance and drug-induced conformational transitions in altered-function mutants of the multidrug transporter P-glycoprotein. Biochemistry, 2001,40: 4332-4339.
中国生物制品学杂志
2003年 第5期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部