多发性抽动症男童15例血清睾酮、雌二醇及孕酮测定意义

Detection of serum testosterone,estradiol and progesterone in children with tourette syndrome

目的 研究性激素与儿童多发性抽动症 (TS)的发病关系。方法 应用放射免疫分析法测定 15例TS男童及 2 0例对照组儿童血清睾酮 (T)、雌二醇 (E2 )及孕酮 (P)水平。结果 1.TS组血清T较对照组显著升高 (P <0 .0 1) ,血清E2 在TS组略降低 ,但与对照组比较无显著性差异 (P >0 .0 5 ) ,TS患儿血清P较对照组显著降低 (P <0 .0 1)。 2 .TS组血清T/E2 和T/P均较对照组显著升高 (P <0 .0 1)。

Objective To investigate the relationship between sexual hormone and children with tourette syndrome (TS).Methods Radioimmunoassay was applied to test the plasma level of testosterone(T) ,estradiol (E 2) and progesterone(P) in 15 male children with TS and 20 normal children as control group.Results 1.The plasma level of T in sick children was significantly higher than that in normal children(P<0.01) ; the plasma level of E 2 was a little lower in sick children;there was no significant difference between each experimental and control group (P>0.05).The plasma level of testosterone in sick children was significantly lower than that in normal children (P<0.01).2.The ratio of T/E2 and T/P was significanty high in TS children (P<0.01).Conclusion The imbalance of the ratio of sexual hormone may play a key role in TS.