蕈样霉菌病肿瘤期的临床研究

The optimum treatment of mycosis fungoides with cancerous stage

目的探讨放疗联合化疗免疫治疗蕈样霉菌病肿瘤期的临床疗效。方法 1 96 7年 1月至 1 996年 1 2月收治 39例蕈样肉芽肿肿瘤期患者 ,放疗和化疗 ,IFN a组 (RT +CT +IFN -a) 2 3例 ,化疗和IFN -a组 1 6例。放疗采用全身电子束照射 (TSEI) ,总剂量 4 0Gy。化疗采用COPP方案 4～6周期。IFN a连用 4周。结果TSEI +COPP +IFN -a组中局部症状缓解率较COPP +IFN -a组高 ,两组有效率分别为 6 5 .2 % ,31 .3% (P <0 .0 5 )。两组 2年生存率为 6 9.6 % ,37.5 % (P <0 .0 5 ) ;5年为 34.8% ,1 8.8% (P >0 .0 5 )。结论TSEI联合治疗能提高局部有效率 ,患者

Objective To find out the adequate treatment of mycosis fungoides with cancerous stage by comparing two different protocols. Methods 39 patients with mycosis fungoides with cancerous stage were treated with chemotherapy and immunotherapy, 23 of them plus radiotherapy. The method of radiotherapy was total skin electron orradiation (TSEI), the dose total was 40Gy. The chemotherapy regimen was COPP for 4～6 cycles. The immunotherapy utilized IFN-a for 4 weeks. Results The remission rate of symptoms was higher in radiotherapy group. The rate of local control of two group was 65.2%, 31.3% ( P <0.05)respectively. The 2 year survival rate: TSEI+COPP+IFN-a group 69.6% COPP+IFN-a group 37.5%( P <0.05); The 5 year: TSEI+COPP+IFN-a group34.8%, the other 18.8%( P >0.05)respectively. Conclusion TSEI combination therapy elevate the rate of local control and the 2 year survival rate.