尖锐湿疣患者外周血Th1/Th2淋巴细胞比的改变

Changes in peripheral blood Th1/Th2cell balance in patients with condyloma acuminatum

目的探讨CA患者Th1/Th2淋巴细胞分布失衡情况及其与发病的相关性。方法采用流式细胞分析技术检测40例CA患者及20例健康志愿者的外周血CD4+ T淋巴细胞中胞内细胞因子(IFN-γ、IL-4),并分析Th1/Th2比值在CA发病中的作用。结果CA患者外周血分泌IFN-γ的Th1细胞显著减少(P<0.05),而分泌IL-4的Th2细胞显著增高(P<0.05);Th1/Th2比值降低,与健康对照组相比有显著差异(P<0.01)。结论CA患者存在Th1/Th2淋巴细胞分布失衡情况。外周血中Th1细胞减少,Th2细胞增多并相对占优势。Th1/Th2淋巴细胞平衡在CA发病机制及复发中具有重要作用。

Objective To explore the association of peripheral blood T helper type 1 (Th1) and type 2 (Th2) imbalance with the occurrence of condyloma acuminatum (CA). Methods Interferon-γ(IFN-γ) and interleukin-4 (IL-4) secreted by CD4 + T-cells were detected by flow cytometry in 40 patients with CA and 20 healthy volunteers, and significance of Th1/Th2 cell ratio in the etiology of the CA was analyzed. Results Peripheral blood Th1 cells that secreted IFN-γwere significantly de-creased in number in patients with CA (P<0.05), while Th2 cells producing IL-4 increased (P<0.05). The Th1/Th2 cell ratio was significantly reduced in CA patients as compared with the health control subjects (P<0.01). Conclusion Increases of Th2 cells and decrease of Th1 cells in the peripheral blood of CA patients result in relative Th2 predominance and breach the Th1/Th2 balance, which may play an important role in the etiology and recurrence of CA.