湿热环境下密闭性功能敷料护理伤口对β-内啡肽的影响

Effect of occlusive wound dressing supplemented with antiphlogistic and analgesic agents on plasma beta-endorphin in hot and humid environments:a study in pigs

目的观察湿热环境下的伤口经密闭性功能敷料处理后血浆β-内啡肽(β-EP)的变化。方法模拟湿热环境,建立猪创伤模型,以密闭性功能敷料处理后,测定各时间段血浆β-EP含量、呼吸频率及心率值并与未采用敷料的对照组进行比较。结果实验组的血浆β-EP含量显著低于对照组(P<0.05),且热暴露8 h和损伤后24 h与伤前无统计学意义(P>0.05)。热暴露时,实验组的呼吸频率及心率值变化幅度显著低于对照组(P<0.05)。结论该敷料具有抑制血浆β-EP的高峰值及呼吸和心率的增加幅度。

Objective To study the changs of plasma β-endorphin (β-EP) in pigs with traumatic injury after occlusive wound dressing supplemented with antiphlogistic and analgesic agents in hot and humid environments (HHE). Methods Traumatic models were established in 10 pigs, 5 of which received antiphlogistic- and analgesic-supplemented occlusive dressings of the wounds (experiment group, EG), while the rest pigs were assigned to control group (CG) to receive routine wound man-agement. The pigs in both groups were then exposed to artificial HHE and at different time points during the exposure, the plasma β-EP level, respiratory frequency and heart rates were measured respectively. Results The plasma β-EP concentra-tion of EG was significantly lower than that of CG (P<0.01) after the injury, but in both groups, the levels before the injury were similar to those measured at hour 8 during HHE exposure and at hour 24 following the injury. The variation range of the respiratory frequency and heart rates during HHE exposure were significantly smaller in EG than CG (P<0.01). Conclusion This supplemented occlusive wound dressing can help restrain the peak of plasma β-EP level and the variation range of respi-ratory frequency and heart rates of pigs exposed to HHE.