期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

神经毒素对电压门控钠通道受体靶点的变构调制 被引量：2

Interallosteric modulation of neurotoxins on Na ^+ channel receptor binding sites
下载PDF
导出
摘要 电压门控钠通道 (VGSC)是许多天然生物神经毒素特异作用的靶受体。全面探明并深刻剖析各种神经毒素与钠通道受体靶点的结合特性以及彼此间的相互变构调制 ,不仅有助于丰富通道蛋白组学、通道药理与毒理学等创新知识 ,也是研制针对性钠通道受体新药和构建环保型生物农药的前提条件。本文侧重各种神经毒素对电压门控钠通道受体靶点的变构调制研究作一简要的进展情况概述。 Voltage gated Na + channel(VGSC)is the target of numerous natural neurotoxins. Clarifying the binding properties and interallosteric modulation of neurotoxins on VGSC is valuable not only for enlarging the knowledge of channel proteomics, channel pharmacology and toxicology, but also for designing new channel specific medicine and biologic pesticide. This short communication will briefly introduce the advance on interallosteric modulation of neurotoxins on Na + channel receptor binding cites. \[
作者 谭淼 吉永华
机构地区 中国科学院上海生命科学研究院生理所神经生物学重点实验室
出处 《中国神经科学杂志》 CSCD 2003年第4期264-267,共4页
基金 国家 973项目 ( 19990 5 40 0 1)资助课题
关键词 神经毒素 电压门控钠通道受体靶点 变构调制 受体靶点 变构调制 neurotoxin voltage gated sodium channel allosteric modulation receptor binding site
分类号 R33 [医药卫生—人体生理学]
  • 相关文献

参考文献28

  • 1Catterall WA. Cellular and molecular biology of voltage-gated sodium channels[J]. Physiol Rev, 1992, 72: S15-S48.
  • 2Catterall WA. Molecular properties of voltage-sensitive sodium channels[J]. Ann Rev Biechem, 1986, 55 : 953-985.
  • 3Catterall WA. Activation of the action potential Na^+ ionophore by neumtoxins. An allosteric model [ J ]. J Biol Chem, 1977, 252 :8660-8668.
  • 4Cattendl WA. Morrow CS, Daly JW, et al. Binding of batrachotoxinin A 20-alpha-benzoate to a receptor site associated with sodium channel in synapic nerve dending particles [ J ]. J Biol Chem,1981,256: 8922-8927.
  • 5Cattemll WA. Risk M. Toxin T46 from Ptychodiscus brevis (formealy Gymnodlrdum breve ) enhances activation of sodium channels by veratrldine[J]. Mol Pharmacol, 1981. 19:345-348.
  • 6Cestele S, Sampierl F, Rochat H, et al. Tetrodotoxin reverses brevetaxin allosterlc inhibition of scorpion alpha-toxin binding on rat brain sodium channels[J]. J Biol Chem, 1996, 271: 18329-18332.
  • 7Lipkind GM, Fozzard HA. A structural mode of the tetrodotoxin and saxitoxin binding site of Na^+ channel[J]. Biophyn J, 1994,66 : 1-13.
  • 8Yang L, Kao CY. Action of chiriquitoxin on frog skeletal muscle fiben and implications for the tetrodotoxin/saxitoxin receptor[ J]. J Gen Physiol, 1992, 100: 609-622.
  • 9Cvstele S, Con:Ion D. Depolarization differentially affects allosteric modulation by neurotoxins of scorpion α-toxin binding on voltagegated sodium channels [ J ]. J Neurochem ,1998, 70: 1217 -1226.
  • 10Jover E, Marlin-Moutot N, Couraud F, et al. Binding of scorpion toxin to rat brain synaptosoma] fraction. Effects of membrane potential, ions and other neurotoxins[ J]. Biochemistry, 1980, 19: 463-467.

同被引文献24

引证文献2

二级引证文献3

中国神经科学杂志
2003年 第4期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部