摘要
电压门控钠通道 (VGSC)是许多天然生物神经毒素特异作用的靶受体。全面探明并深刻剖析各种神经毒素与钠通道受体靶点的结合特性以及彼此间的相互变构调制 ,不仅有助于丰富通道蛋白组学、通道药理与毒理学等创新知识 ,也是研制针对性钠通道受体新药和构建环保型生物农药的前提条件。本文侧重各种神经毒素对电压门控钠通道受体靶点的变构调制研究作一简要的进展情况概述。
Voltage gated Na + channel(VGSC)is the target of numerous natural neurotoxins. Clarifying the binding properties and interallosteric modulation of neurotoxins on VGSC is valuable not only for enlarging the knowledge of channel proteomics, channel pharmacology and toxicology, but also for designing new channel specific medicine and biologic pesticide. This short communication will briefly introduce the advance on interallosteric modulation of neurotoxins on Na + channel receptor binding cites. \[
基金
国家 973项目 ( 19990 5 40 0 1)资助课题