老年性痴呆患者血清叶酸和维生素B_(12)的临床观察

The levels of serum folate and vitaminB_(12) in the patients with senile dementia

目的 了解老年性痴呆患者叶酸和维生素B12 水平 ,并探讨二者与痴呆的关系。方法 研究对象为 6 0岁以上的老年人 10 4例 ,患有老年性痴呆者 76例 ,其中老年性痴呆 (AD) 33例 ,血管性痴呆 (VD) 4 3例 ,健康老年者 2 8人作为对照组。对所有研究对象进行临床病史询问、内科和神经科查体 ,空腹取血检测血清叶酸和维生素B12 。结果 老年性痴呆患者叶酸的平均水平为 (7.6 5± 2 .4 8)ug/L(AD)和 (8.5 4± 3.34)ug/L(VD) ,维生素B12 的平均水平为 (312 .4 3± 182 .5 )ng/L(AD)和 (713.5 8± 6 2 5 .94 )ng/L(VD) ,对照组叶酸和VitB12 的平均水平分别为 (11.35± 3.76 )ug/L和 (5 0 7.8± 4 5 2 .85 )ng/L ,分别与对照组比较有显著性差异 (P <0 .0 5 )。结论 老年性痴呆者与血清低叶酸水平有关 ,而与低维生素B12 水平无关。

Objective To observe the levels of serum folate and vitaminB 12 in the patients with dementia.Methods The age of the subjects were 60 years or more: the senile dementia of Alzheimer type (AD) group (33); the vascular dementia (VD) group (43), and the health control groups (28). The levels of serum folic acid and vitamin B 12 of fast blood were tested in all patients.Results The levels of serum folate and vitamin B 12 in the senile dementia with AD and VD were ( 7.65 ± 2.48 ) ug/L (AD) vs ( 8.54 ± 3.34 ) ug/L(VD) and ( 312.43 ± 182.5 ) ng/L (AD) vs ( 713.58 ± 625.94 ) ng/L(VD),contrasted to the control group ( 11.35 ± 3.76 ) ug/L and 507.8 ± 452.85 ) ng/L there were significance difference ( P < 0.05 ) among them.Conclusions The senile dementia is associated with the lower levels of folate and not with the levels of vitaminB 12 .