摘要
目的 探讨急性一氧化碳中毒后迟发性脑病 (DEACMP)患者脑神经元的损伤。方法 应用酶联免疫分析法测定 4 0例DEACMP患者和 30例对照组血清及脑脊液 (CSF)神经元特异性烯醇化酶 (NSE)浓度。应用直线相关分析方法分析NSE浓度与病情严重程度以及预后的关系。结果 对照组血清和CSFNSE浓度分别为 (8.0 1± 6 .78)ug/L和 (6 .74± 5 .31)ug/L。观察组血清和CSFNSE浓度分别为 (15 .2 1± 6 .78)ug/L和 (13.6 1± 5 .2 7)ug/L。观察组与对照组之间存在明显的统计学差异 (P <0 .0 1)。NSE浓度与病情严重程度及预后之间存在相关性。结论 DEACMP患者血清及CSFNSE浓度明显增高 ,NSE浓度的高低可作为脑神经元损伤的量化指标 ,也可能是判断病情、估计预后的重要参数。
Objective To explore neuronal damage in patients with delayed encephalopathy after acute carbon monoxide poisoning (DEACMP).Methods The neuron specific enolase (NSE) levels in serum and CSF were determined by ELISA in 40 patients with delayed encephalopathy after acute carbon monoxide poisoning and 30 contrlos.The relations were analyzed among NSE levels and the extent of the neurologic damage and prognosis.Results The concentrations of serum NSE and CSF NSE were 8.01 ± 6.78 ug/L and 6.74 ± 5.31 ug/L respectively in the controls. The concentrations of serum NSE and CSF NSE were 15.21 ± 6.78 ug/L and 13.61 ± 5.27 ug/L respectively in the patients with DEACMP. The difference of NSE levels was significant between the controls and the cases with DEACMP ( P < 0.01 ). There was a significant correlation of NSE levels with the extent of the neurologic damage and prognosis.Conclusion The levels of the serum NSE and CSF NSE remarkably increase in the patients with DEACMP. The alternation of NSE not only provides quantitative information about the degree of certain neurologic lesions, but also possibly serves as an important parameter of assessing the prognosis.
出处
《卒中与神经疾病》
2003年第4期216-218,共3页
Stroke and Nervous Diseases
