通心络对X综合征患者血管内皮功能的影响

The effect of Tongxinluo on the vascular endothelial function in patients with syndrome X

目的 观察通心络对X综合征患者血管内皮功能异常的保护作用。方法 采用随机、对照、单盲方法将37例X综合征患者分为通心络组(n=19)和常规治疗组(n=18)。疗程均为8周。治疗前后分别采用高分辨血管超声检测肱动脉血流介导性舒张(FMD)功能变化,并测定血中内皮素-1(ET-1)含量。结果 通心络组治疗后肱动脉FMD、ET-1较治疗前有显著改普(P<0.01),与常规治疗组比较有非常显著性差异(P<0.01)。结论 通心络可显著改善X综合征患者的血管内皮功能异常。

Objective To investigate the protective effect of Tongxinluo on the vascular endothelial function in patients with syndrome X.Methods 37 patients with syndrome X were divided into two groups by using a randomized, control and single blind method,Tongxinluo group( n = 19)and routine treatment group( n = 18) ,with a treatment couse of 8 weeks for both groups.The flow-mediated dilatation(FMD)function in brachial artery was measured by high-resolusion ultrasound and plasma endothelin-1( ET-1) was detected before and after treatment. Results The FMD function in brachia lartery and the level of plasma ET-1 in Tongxinluo group were improved obviously, there was a significant difference between Tongxinluo group and routine treatment group( P < 0.01.)Conclusion Tongxinluo can improve the vascular endothelial function of paitents with syndrome X.