慢性阻塞性肺疾病继发院内真菌感染的危险因素及药物经济学分析

Analyses of Dangerous Factors and Pharmacoeconomy in Chronic Obstructive Pulmonary Disease(COPD) Complicated with Fungus Infection in the Hospital

目的 :分析慢性阻塞性肺疾病 (COPD)急性加重期继发院内深部真菌感染的危险因素及其药物治疗的经济学意义。方法 :查阅 2 0 0 0年 10月～ 2 0 0 1年 10月我院 74例COPD急性加重期患者的病历 ,对其抗生素应用种类、应用时间、糖皮质激素应用情况、真菌感染部位、菌种类型、抗真菌药物、住院费用及平均住院日进行分析。结果 :高龄及营养状况差是院内真菌感染的危险因素之一 ,而广谱抗生素长期大量应用则是造成真菌感染的重要因素 ,另外 ,合并应用糖皮质激素也是院内真菌感染的又一发病因素。继发院内真菌感染 ,明显延长了住院时间 ,增加了住院费用。结论 :减少院内真菌感染 ,对遏制医疗费用的增长 ,节约国家的卫生资源 。

OBJECTIVE:To analyze dangerous factors and pharmacoeconomy in acute aggravated period of COPD complicated with deep fungus infection. METHODS: By reviewing records of 74 cases with COPD in acute aggravated period during Oct,2000 to Oct,2001, variety and duration of antibiotics, application of steroid hormones, fungus infectious area, variety of fungus, drugs against fungus, hospitalized expenses and average hospitalized duration were analyzed. RESULTS: Seniority and insufficient nutrition was one of the dangerous factors, but long-term and large dose usage of wide spectrum antibiotics was the major factor for fungus infection. In addition, combined with steroid hormones was also one factor. Complicated with fungus infection in the hospital obviously lengthened hospitalized duration and increased expenses. CONCLUSION: Decreasing fungus infectious rate in the hospital is of great significance for inhibiting the increase of medical expenses and saving health resources of our country.