摘要
This article summarizes the achievements of the authors' group in the area of biocatalyst catalyzed organic reactions in recent 10 years. A strain of Geotrichum sp. obtained by screening is capable of stereoselectively reducing a number of carbonyl compounds. In many cases, the stereochemistry is complementary with that obtained by baker's yeast. Therefore, this micro organism provides a useful pathway to the preparation of alcohol compounds with specific configurations. On the other hand, a number of plant sources have been screened for oxynitrilases and the hydrocyanation reactions of various arylcarboxaldehydes have been investigated. A “micro aqueous reaction system' was invented, by which a series of novel optically active cyanohydrins were prepared. On this basis, a high through put continuous reaction system has been designed. This paper also describes examples of the syntheses of bio active compounds by using the optically active compounds obtained from the above mentioned catalytic reactions as precursors.
This article summarizes the achievements of the authors' group in the area of biocatalyst catalyzed organic reactions in recent 10 years. A strain of Geotrichum sp. obtained by screening is capable of stereoselectively reducing a number of carbonyl compounds. In many cases, the stereochemistry is complementary with that obtained by baker's yeast. Therefore, this micro organism provides a useful pathway to the preparation of alcohol compounds with specific configurations. On the other hand, a number of plant sources have been screened for oxynitrilases and the hydrocyanation reactions of various arylcarboxaldehydes have been investigated. A “micro aqueous reaction system' was invented, by which a series of novel optically active cyanohydrins were prepared. On this basis, a high through put continuous reaction system has been designed. This paper also describes examples of the syntheses of bio active compounds by using the optically active compounds obtained from the above mentioned catalytic reactions as precursors.
基金
theNationalNaturalScienceFoundationofChinaandStateMinistryofScienceandTechnology (No .G2 0 0 0 0 775 0 6)
