摘要
Enantioselective conjugate addition of diethylzinc to chalcone was carried out in the presence of Ni(acac) 2 complexed with five pyrrolidinylmethanols derived from L proline. ( S ) N Benzyl 2 (1 hydroxy 1 methylethyl) pyrrolidine was found to be the best ligand in asymmetric conjugate addition among the five ligands. The products were obtained with up to 70% ee . The configuration of the product was determined jointly by the substituents on the carbon of the hydroxy group and the nitrogen atom.
Enantioselective conjugate addition of diethylzinc to chalcone was carried out in the presence of Ni(acac) 2 complexed with five pyrrolidinylmethanols derived from L proline. ( S ) N Benzyl 2 (1 hydroxy 1 methylethyl) pyrrolidine was found to be the best ligand in asymmetric conjugate addition among the five ligands. The products were obtained with up to 70% ee . The configuration of the product was determined jointly by the substituents on the carbon of the hydroxy group and the nitrogen atom.
基金
theNationalNaturalScienceFoundationofChina (No .2 9972 0 16andQTProgram )
theTeachingandResearchAwardProgramforOutstandingYoungTeachersinHigherEducationInstitutionsoftheMinistryofEducationofChina
