夏枯草及抗炎1号注射液经肝动脉联合灌注治疗大鼠晚期肝癌的实验研究

Therapeutic Efficacy of Prunella Vulgaris L and Kangyan No.1 Infused Via Hepatic Artery Against Advanced Primary Liver Cancer in Rat

目的:观察夏枯草及抗炎1号注射液经肝动脉联合灌注对大鼠晚期肝癌的治疗作用。方法:建立30只二乙基亚硝胺(DEN)诱发大鼠晚期原发性肝癌模型,随机分为中药组、化疗组和盐水组,每组各10只。经胃、十二指肠动脉至肝固有动脉分别灌注生理盐水0.5mL、夏枯草注射液0.6g/kg+抗炎1号注射液0.45g/kg、顺铂(DDP)4mg/kg+羟基喜树碱(HCPT)1.5mg/kg+5-氟脲嘧啶(5-FU)34mg/kg。结果:与化疗组和盐水组比较,中药组大鼠的一般情况较好,肝重/体重低,病理性肝损害轻,生存率高(90％对60％,70％,P〈0.05)。结论:经肝动脉联合灌注夏枯草及抗炎1号注射液较灌注化疗药物对诱发性大鼠晚期肝癌具有更好的作用。

Objective: To observe the therapeutic efficacy of prunella vulgaris 1 and kangyan no.I infused via hepatic artery against advanced Primary Liver Cancer in rat. Methods: 30 rats with advanced Primary Liver Cancer induced by DEN were divided into 3 groups randomly. Each group has 10 rats and were infused with Normal Saline, Prunellae Vulgaris L and Kangyan No.I, and chemiotherapy (include DDP+HCPT+5-FU) from gastroduodenal artery into hepatic artery respectively. The survival rate ,general state Jiver weight /rat weight and the hepatic pathomorhiesm were compared among 3 groups. Result: Compared with other groups TCM group showed good result in the survival rate (90% aginst 60 %;70% P<0.05) , general state , pathologic Lesion of liver and liver weight /rat weight was lower than NS group significantly, but had no statistics difference from chemiotherapy group(P >0.05). Conclusion: The efficacy of prunellae vulgaris 1 and kangyan no.I infused via hepatic artery was better than other groups in treating rat advanced Primary Liver Cancer induced by DEN.