摘要
选择充血性心衰 (CHF)患者 5 0例随机分为两组 ,对照组 (2 5例 )予常规药物治疗 ,左旋卡尼汀 (L- CN)组 (2 5例 )予常规药物 +L- CN治疗。采用化学定量法检测两组血清丙二醛 (MDA)和超氧化物歧化酶 (SOD)含量。结果发现 ,治疗前 L- CN组和对照组比较 ,血清 SOD和 MDA水平没有显著性差异 ;治疗后 L- CN组和对照组比较 ,SOD水平显著上升 ,MDA水平显著下降 (P<0 .0 1)。提示 L- CN可能对
This paper is to investigate the effects of L carnitine( L CN) on levels of superoxide dismutase(SOD) and malondialdehyde(MDA) in patients with congestive heart failure(CHF). Fifty patients with CHF were randomly divided into control group and L CN group( n =25). The control group received routine medication: digitalis,diuretics,vasodilator,ACEI and β receptor blocker while the L CN group was given intravenous L CN 3.0 g for 10 d. The blood samples for assay of serum SOD and MDA levels were taken before and after treatment. The concentration of SOD in L CN group was significantly increased [(110.15±4.19) vs (94.54±4.0) μU/ml, P <0.01] and the levels of MDA significantly decreased compared with that of control group [(4.81±1.83) vs (7.71±1.18) μmol/ml, P <0.01]. L CN may protect myocardium in CHF patients.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
2003年第8期916-917,共2页
Academic Journal of Second Military Medical University
基金
全军医学科学技术研究"十五"规划面上课题基金( 0 1M0 0 2 ) .
