微柱法测定糖化血红蛋白及对血糖控制的评价

Glycated hemoglobin witn micro-column test and evaluation of blood glucose control

目的 糖化血红蛋白 (HbA1c)测定是监测血糖控制程度的重要指标 ,在糖尿病 (DM)的治疗和血管并发症的防治中起着重要作用。方法 采用微柱法 (离子交换层析 ,BIO RAD试剂 ) ,测定了 87例糖尿病患者的全血HbA1c含量 ,并对该方法进行了一般性评价。结果 当DM控制较好时其浓度值在 <6 .2 %范围内 ;当DM控制较差时其浓度可高至正常的 2～ 3倍。即HbA1c浓度 >8% ,说明血糖控制程度差 ,提示临床增加用药量 ;HbA1c浓度在 7%～ 1 0 %范围提示血糖控制程度较好 ,如HbA1c浓度 <6 %说明治疗效果好 ,血糖已降至正常或无糖尿病水平。结论 血液中的葡萄糖测定仅反映即刻血糖水平 ,而HbA1c值可判断

Objective To investigate the clinical significance of glycated hemoglobin A 1c (HbA 1c ) and its role as a useful clinical marker in the evaluation for the glucose metabolism in patients with diabetes mellitus . Methods The 87 patients with diabetes mellitus were enrolled into the study. HbA 1c were testes with micro column test in the diabetes mellitus . Results Prevalence rates of HbA 1c <6.2% , HbA 1c 6.2～8.0% and HbA 1c >8.0% were 32.18%, 31.04%,36.78% respectively in 87 diabetic patients. Conclusion Blood glucose is only a marker for instant plasma glucose level . Measurement of HbA 1c is significant in evaluation of the two months average level of glycemic excursion and HbA1c is closely correlate to clinical manifestation of patients with diabetes mellitus.