血清胰岛素样生长因子-1与肥厚型心肌病左室肥厚的相关性研究

The relationship between circulating insulin-like growth factor-1 and left ventricular hypertrophy in the patients with hypertrophic cardiomyopathy

目的 :探讨肥厚型心肌病 (HCM)患者胰岛素样生长因子 - 1(IGF - 1)与HCM心室肌肥厚程度的关系。方法 :分 3组 :正常对照组 (n =2 9)、高血压伴左室肥厚组 (n =2 6 )和HCM组 (n =18)。以超声心动图测算左室重量指数 ,以放射免疫法测定血清IGF - 1水平 ,比较 3组血清IGF - 1水平 ,分析IGF - 1水平和心室肌肥厚程度的相关性。结果 :HCM组和高血压伴左室肥厚组血清IGF - 1水平无统计学差异 ,但两组均显著高于正常对照组 (p <0 .0 1)。血清IGF - 1与左室重量指数高度相关 (r =0 .91,p <0 .0 1)。结论 :IGF - 1可能参与肥厚型心肌病心肌肥厚发生发展的过程。

Objective: To study the relationship between circulating insulin-like growth factor-1 and left ventricular hypertrophy in the patients with hypertrophic cardiomyopathy. Methods: Persons in study were divided into three groups: 18 with hypertrophic cardiomyopathy(HCM), 26 with essential hypertension complicated with left ventricular hypertrophy(LVH) and 29 as control. Echocardiography was used to determine the left ventricular mass index (LVMI), the levels of circulating insulin-like growth factor-1(IGF-1) were determined by radio-immunoassay. We compared the levels of IGF-1 among three groups and studied the relationship between circulating IGF-1 and LVH in the patients with HCM. Results: The level of circulating IGF-1 was significantly higher in the HCM group than the control(p<0.01), but was the same with the patients having essential hypertension complicated with left ventricular hypertrophy. There was significantly positive correlation betweenIGF-1 and LVMI(r=0.91, p<0.01). Conclusions: The insulin-like growth factor-1 may play a crucial role in the process of left ventricular hypertrophy in patients with hypertrophic cardiomyopathy.