常用药物致肝损害临床分析

Clinical Analysis of Drug-induced Liver Damage

目的 通过 194例药物性肝损害的分析 ,了解引起药物性肝损害 (DIH)的发病情况、发病因素及造成的危害。 方法 采用回顾性临床调查分析 ,统计了 194例的发病情况。 结果 分析表明长期使用抗生素类药物是导致慢性淤胆和肝细胞损伤型主要发病因素 ,出现淤阻性黄疸或与肝炎临床症状相似的疾病 ,出现急性肝坏死或肝昏迷 ,死亡率尚高。 结论 指导合理用药 ,监控抗生素的用量和用药时间 。

Objective To find out the causes and risks of drug-induced liver damage disease(DIH).Methods retrospective investigation was adopted on194 cases with adverse drug-induced liver damage.Results administration of antibiotcs is main reason leading to chronic hepatic offinis or liver-cell damage, which exhibits acute liver necrosis or liver coma,the mortality is high.Conclusion drug-induced liver damage could be reduced by rational administration of antibiotics i、e,shortening the antibiotics using time and monitoring antibiotics dosages.