缺氧缺血性脑病细胞因子变化的研究

Study of Changes of Cytokines in HIE

目的 探讨新生儿缺氧缺血性脑病外周血IL - 6、IL - 8与TNF -a变化的临床意义。 方法 HIE组及对照组均于出生后 2 4h内采用放射免疫法测定外周血IL - 6、IL - 8与TNF -a。 结果 HIE组IL - 6、IL- 8水平显著低于对照组 ,而TNF -a明显升高。 结论 IL - 6、IL - 8、TNF -a变化与HIE病情呈正相关 ,它们可能参与了新生儿缺氧缺血性脑损伤的某些发病过程。

Objective explore the change and clinical significance of Il-6、IL-8 and TNF-α in peripheral blood in HIE.Methods IL-6、IL-8、TNF-α in peripheral blood were measured by radio immunoassay both in HIE groups and control groups within 24 hours after born.Results the level of IL-6、IL-8、in HIE groups is much lower than control groups but TNF-α increased greatly.Conclusion the change of IL-6、IL-8、TNF-α was associated with severity of HIE with positive relationship. They might have joined the course of disease in HIE brain damage