尿激酶 肝素治疗急性脑梗死临床研究

Clinical Research on Treatment of Acute Cerebral Infarction through Carotid Artery Injection of Small Doses Urokinase and Heparin

目的 研究小剂量尿激酶与肝素治疗急性脑梗死的疗效及安全性。 方法 将 10 0例急性脑梗死患者随机分为治疗组和对照组 (各 5 0例 ) ,治疗组给以小剂量尿激酶 10万U加生理盐水 5 0ml颈动脉注射 ,另给以肝素 5 0～ 10 0mg加生理盐水 2 5 0ml静脉滴注 ,每日一次 ,共七天。对照组给以复方丹参 2 0ml加生理盐水2 5 0ml,静脉滴注 ,每日一次 ,连用 15d ,两组均合并用甘露醇、阿斯匹林等。 结果 治疗后一周及治疗后一个月进行神经功能缺损状态评分 ,治疗组分别为 8.2± 2 .9,9.6± 4 .6 ,对照组分别为 4 .4± 2 .3,7.3± 2 .4 ,两组对比有显著差异 (P <0 .0 5 ) ,无出血并发症。 结论 小剂量尿激酶与肝素治疗急性脑梗死疗效肯定 。

Objective To make a study of the curative effect and security of small doses urokinase(UK) and heparin treating acute cerebral infarction.Methods We divided at random 100 acute cerebral infarction patients into two groups,the treatment group and the control group,each 50 patients.The treatment group was given carotid artery injection of small doses UK of 100,000U with 50ml of sodium chloride injection,in addition to intravenous perfusion of 50-100mg of heparin with 250ml of physiological saline.This was done once a day for a week.At the same time the control group was given 20ml of compound salvia miltiorrhiza injection in 250ml of sodium chloride injection in the form of intravenous perfusion,once a day for 15 days.Meanwhile both groups were given mannitol,aspirin and so on.Results When the neurility coloboma of the patients was graded a week and a month after the treatment,the following data were obtained:the treatment group was separately 8.2±2.9and 9.6±4.6while the control group was separately4.4±2.3and 7.3±2.4,which show the notable divergence between the two groups(P<0.05).Neither group results in hemorrhagic complication.Conclusion Treating acute ceebral infarction with small doses UK and heparin has a positive curative effect and reliable security.