VEGF、VEGF-C、flt-4在乳腺癌组织中的表达及临床病理分析

Expression of vascular endothelial growth factors VEGF, VEGF-C and flt-4 in breast cancer and its clinical pathological analysis

目的:探讨乳腺癌组织中VEGF、VEGF-C、flt-4蛋白的表达水平、相互关系及临床意义。方法:采用免疫组织化学ABC法,检测82例乳腺癌石蜡标本中VEGF、VEGF-C、flt-4蛋白的表达水平。结果:乳腺癌标本中VEGF、VEGF-C、flt-4蛋白的阳性表达率分别为57.3％、46.3％、50.0％,VEGF-C与flt-4蛋白的表达呈正相关。但与乳腺癌组织病理学分型、肿瘤大小和分级无关。结论:VEGF-C、flt-4蛋白的表达与乳腺癌淋巴结转移有关,并可能协同作用于淋巴结转移过程。

Purpose: To study the expression of VEGF, VEGF-C, fit-4 in breast cancer and its relationship with lymph node metastasis and explore the significance of lymphangiogenesis on metastasis via lymphtics. Methods: Paraffin-embedded specimens from 82 patients with primary breast cancer who had undergone radical mastectomy with lymph node dissection were studied. VEGF, VEGF-C, flt-4 expression were investigated by immunohistochemical staining. Results: Positive staining for VEGF, VEGF-C, flt-4 were observed in some breast cancer cells. Furthermore, the expression of VEGF-C, flt-4 were significantly higher in lymph node-positive group than in node-negative group. Correlation was found within the expression of VEGF-C, flt4 also. Conclusions: Clinical significance was found between VEGF-C, flt-4 expression and lymph-node metastasis in breast cancer, and may be involved in the metastatic process.