尿液核基质蛋白_(22)在膀胱移行上皮癌筛检中的价值

Evaluation of urinary NMP_(22) in the detection of transitional cell carcinoma of bladder

目的:评价尿核基质蛋白22(NMP22)在膀胱移行上皮癌筛检中的意义。方法:采用酶联免疫法检测28例膀胱移行上皮癌、25例泌尿系良性疾病和10例泌尿系非移行上皮癌患者尿NMP22水平,并与尿脱落细胞学检查进行比较。结果:膀胱移行上皮癌患者尿NMP22中位值为66.5u/ml,明显高于泌尿系良性疾病和非移行上皮癌,与肿瘤分期、分级、数目无关,以10u/ml为临界,诊断膀胱癌敏感性为85.7％,特异性为60％,尿脱落细胞学检查敏感性为32.1％,特异性为100％。结论:尿NMP22检测膀胱移行上皮癌敏感性、特异性均较高,可用于膀胱移行上皮癌的筛选和术后随访。

Purpose: To assess the clinical diagnostic value of urinary NMP2, for transitional cell carcinoma of bladder. Methods: The level of NMP22 was measured in the urine of 28 patients with transitional cell carcinoma of bladder, 25 patients with benign urinary tract conditions and 10 patients with non-transitional cell carcinoma by ELISA and compared with urine cytology. Results: The median level of urinary NMP22 for transitional cell carcinoma of bladder was 66. 5u/ml and significally higher than that for non-transitional cell carcinoma and benign urinary tract conditions. The level of NMP22 was not associated with the pathological grade, clinical stage and the number of tumors ( P > 0. 05) . The sensitivity and specificity of NMP-,2 in diagnosing transitional cell carcinoma of bladder were 85. 7% and 60% when the cut-off was set 10 u/ml, In contrast, the sensitivity and specificity of urinec cytology were 32. 1% and 100%. Conclusions: Urinary NMP22 can be used to screen and follow up transitional cell carcinomas of bladder with high sensitivity and high specificity.