A群流脑多糖菌苗免疫效果观察

An Observation on the Immunity Effects of Polysaccharose Vaccine against Epidemic Encephalitis Caused by Type A Virus

目的:观察A群流脑多糖菌苗的免疫效果和免疫持久性。方法:采用ELISA检测流脑多糖抗体,对免疫前及免疫后6个月连续观察流脑IgG抗体水平。结果:免疫后抗体较免疫前有明显增长,免疫后1、3、6月抗体几何平均滴度(GMT)之间无显著性差别,免疫后阳转率较高,免疫后1、3、6月四倍增长率分别为83.78％;83.78％;83.55％,而免疫前抗体水平越高,免疫后四倍增长率就越低。结论:免疫后抗体明显增长,阳转率较高,表明菌苗免疫原性与免疫效果好,用ELISA检测流脑IgG抗体的方法来衡量体内的抗体水平是可行的。

Objective: To observe the effect and endurance of the polysaccharose vaccine for prevention of epidemic encephalitis caused by Type A virus. Methods: ELISA was adopted to test the poly-saccharose antibody and continuing observation was conducted on its immune effects in 500 people for 6 months. Results: Antibody liter in subjects obviously increased after immunization. The four-times increasing rates of antibody liter in 1 month, 3 months and 6 months after immunization were 83. 78% , 83. 78% , and 83. 55% respectively. No obvious difference was found belween GMTs. The positive changes were great. A phenomenon was observed that the higher the antibody level before immunization, the lower the four - times increasing rates of antibody afterwards. Conclusions: The obvious increase of antibody level and relatively high positive changes after immunization shows lhat the immuno-genicily and the immunological effects of the vaccine are good. It is feasible to use ELISA melhod in measuring the antibody level.