反应条件对合成2-羟基-4-正辛氧基二苯甲酮的影响

Effect of Reaction Conditions on Synthesis of 2-Hydroxy-4-octyloxybenzophenones

在氢氧化钾作用下 ,加入少量的氯化二甲基双十六烷基铵 ,2 ,4 二羟基二苯甲酮与 1-溴代正辛烷反应可制备紫外线吸收剂 2 -羟基 - 4 -正辛氧基二苯甲酮。考察了不同相转移剂用量、不同水量和不同反应时间对 2 -羟基 - 4 -正辛氧基二苯甲酮产品收率的影响 ,并提出比较合适的反应条件。UV - 2 14 KOH 1-溴代正辛烷 氯化二甲基双十六烷基铵 水物料配比是 0 .0 6 0 .0 7 0 .0 6 0 .0 0 2 0 .2 5(摩尔比 ) ,反应 6小时 ,UV - 5 31的收率是 93.2 % 。

Hydroxy-4-octyloxybenzophenones was prepared by reaction of 2,4-dihydroxybenzophenone with 1-bromoctane by adding Dioctadecyldimethylammonium chloride in KOH. The effect of different phase tremsfer agent, water amount and reaction time on UV-531 yield was investigated.Its optimal condition was pointed out, The ratio of UV-214 to KOH to C 8H 17 Br to dioctadecyldimethylammonium chloride to water was 0.06∶0.07∶0.06∶0.002∶0.25(mol),and the reaction time was 6 h,and the yield of UV-531 was 93.2 %,so dioctadecyldimethylammonium chloride was very good phase agent.