JM216的水合反应及其稳定性影响因素

The Aquation Reactions of JM216 and the Effects of Acid and Light on Its Stability

研究了JM2 1 6的水合反应动力学 ,并考察了光照、稀酸对其稳定性的影响。结果表明 ,JM2 1 6的水合反应为准一级反应 ,反应对JM2 1 6为一级 ,37°C时水合反应表观速率常数为kobs=5 0× 1 0 - 6 min- 1,半衰期t1 2 =96 2 5d。在光照下 ,JM2 1 6溶液稳定。而在稀HCl溶液中 ,随着酸浓度增加 ,JM2 1 6的稳定性降低 ,但在胃液酸度范围、口服用药时间内可保持稳定 ,因此口服用药过程不会影响JM2 1 6的稳定性。

The aquation of JM216 and the effects of acidity and light on the stability of JM216 were studied. The experimental results showed that the aquation of JM216 follows the pseudo-first-order- rate law, of which the observed-rate constant k_ obs is 5.0×1.0 -6 min -1 and the half life period t_ 1/2 is 96.25 days at 37℃. Upon irradiation with 4500±500 lx strong light, JM216 was unstable in aqueous solution .In 0.01～0.1mol/L HCl aqueous solution with the acidity of gastrointestinal environment, JM216 could keep stable for 5 hours. From these results, it can be seen that JM216 survives in gastric environment and may be applied orally.