十二指肠溃疡病人Bf和C_4多态性的检测

Investigation on Genetic Polymorphism of Human Complement Factor B (Bf) and C4 in Patients with Duodenal Ulcer

对80例十一指肠溃疡病人的血清Bf和C_4的多态性进行了检测,结果发现病人的BF*F和C_4B*1基因频率较正常人明显增高(P<0.01)。这两种基因在该病中的相对危险率(RR)及病因分数(EF),BF*F分别为2.1356及0.1164,C_4B*1分别为1.8750及0.2638。而病人BF*S和C_4B*2基因频率较正常人明显降低(P<0.01),它们在该病中的RR值和预防分数(PF),BF*S分别为0.4682和0.4641,C_4B*2分别为0.4787和0.1915。

Allotyping of complement component Factor B (Bf) and C_4 have been performed in 80 cases of patients with duodenal ulcer (DU) , in an attempt to define whether specific alleles were associated with this disease. A significant increase in BF*F and C_4B*1 and significant decrease in BF*S and C_4B*2 gene frequency in patients with DU was found in comparision with that of normal controls (P<0.01) . The relative risk values (RR) and etiological fraction (EF) in patients with DU were 2.1356 and 0.1164 for BF*F, and 1.8750 and 0.2638 for C_4B*1 respectively. The RR and preventive fraction (PF) in patients were 0.4682 and 0.4641 for BF*S, and 0.4787 and 0.1915 for C_4B*2 respectively.