CD_2、CD_3、CD_4和CD_8四种McAb对rHuIL-2诱导人胚胸腺细胞杀伤功能的调节作用

CD_2,CD_3 ,CD_4 and CD_8 McAbs Regulates Cytotoxic Activity of Human Fetal Thymocyte Induced by rHuIL-2

本文观察了人胚胸腺细胞(16～40周龄)对CD_2、CD_3、CD_4和CD_8四种McAb诱导的增殖反应及这四种McAb对rHuIL-2诱导的人胚胸腺细胞杀伤功能的影响。结果提示:除CD_3McAb能诱导很弱的人胚胸腺细胞增殖外,其它三种McAb均不能诱导其增殖;CD_3McAb对rIL-2所诱导的增殖有明显的协同效应,但对IL-2诱导的人胚胸腺细胞杀伤活性却有显著的抑制作用;而CD_4、CD_8两种McAb则有显著的促进作用;CD_2McAb无明显影响。本文还对McAb可能的调节机理进行了讨论。

The regulatory effect of CD_2,CD_3,CD_4 and CD_8 McAbs on human fetal thymocyte cytotoxic activity induced by rHuIL-2 was investigated. It was shown that (1)CD_3 McAb,but not CD_2,CD_4 and CD_8 McAbs could induce the human fetal thymocyte proliferative response; (2)CD_3 McAb could promote rHuIL-2-induced the human fetal thymocyte proliferative response, but suppressed rHuIL-2-induced human fetal thymocyte cytotoxic activity; (3)CD_4 and CD_8 McAbs promoted rHuIL-2-induced human fetal thymocyte cytotoxic activity. These results have significances for understanding the expression and function of differentiation antigen on the human fetal thymocytes.