格列美脲或瑞格列奈联合二甲双胍治疗2型糖尿病的临床观察

Comparative Observations on Therapeatic Efficacy of Glimepiride and Repaglinide with Metformin in Treatment of Type 2 Diadetes

目的:观察格列美脲或瑞格列奈联合二甲双胍治疗2型糖尿病的临床疗效。方法:采用随机、双盲、对照的研究方法,对81例2型糖尿病患者分别给予格列美脲加二甲双胍(A组)、瑞格列奈加二甲双胍(B组)及单用二甲双胍(C组)治疗,起始剂量分别为2mg/d、1.5mg/d.750mg/d,服药后4周、8周根据血糖水平调整剂量。结果:治疗后3组的空腹血糖(FBG)、餐后两小时血糖(2hpBG)和指血糖化血清蛋白水平均较治疗前明显下降(P<0.01);A、B两组治疗后FBG下降程序明显大于C组(P<0.01),但A、B两组间差异无显著性(P>0.05);血脂、血肌苷、血尿酸及24h尿微量白蛋定量均无统计学意义。结论:格列美脲或瑞格列奈联合二甲双胍治疗2型糖尿病能有效地控制血糖。

Objective :To observe the efficacy of glimepiride and repaglinide with metfrmin in treatment of type 2 diabetes. Methods: It was a randomized, controlled, blinded clinical trial, Eighty-one patients with type 2diabotes were randomly divided into 3 groups, The first group (group A) received 2mg/d of glimepiride and 750mg/d of metformin , the second group (group B) received 1.5mg/d of glimepiride and 750mg/d of metformin and the third group (group c)received 750mg/d of metformin only as in itial dose,After treated for 4 and 8 weeks.the doses were adjusted according to fasting blood glucose level.The duration of treatmenf was 12 weeks.Results: Fasting,2h postprandial glucose levels and fruc tosamine were obviously decreased in comparison with baseline of three groups ( P < 0.01). The decreased range of fasting and 2h postprandial glucose levels in group A and B.was more than that in group C( P < 0.01) however, there was no significant difference between group A and B. Conclusion: Climepiride with metfonmn and repaglinide with metfornin are similarly effective and superior to metformin alone in treatment of type 2 diabetes