强骨膏治疗绝经后骨质疏松症的疗效观察

Clinical Observation of "Qianggu Extracts" in Treating Post-menopausal Osteoprosis

为观察强骨膏防治绝经后骨质疏松症 (PMOP)的疗效及机理 ,选择自然绝经 5年以上、骨密度 (BMD)低于同性别峰值骨量 13 %以上无其他合并症、未经治疗的PMOP患者 13 8例 ,随机分为治疗组与对照组。治疗组 10 2例服强骨膏 ,对照组 3 6例服葡萄糖酸钙 ,疗程均为 6个月 ;治疗前后检测股骨颈BMD和骨代谢相关指标。结果 :治疗后 ,治疗组骨痛显著改善 ,BMP平均提高 5 89% ,雌二醇 (E2 )、碱性磷酸酶 (ALP)、血钙 (Ca)显著增高 ,尿吡啶酚 (PYD)显著下降。总有效率为 93 14 %。以上指标明显优于对照组且未出现不良反应。提示强骨膏能有效防治PMOP。

To observe the clinical effects of 'Qianggu Extracts' in the treatment of post-menopausal osteoprosis (PMOP) and its mechanism, 138 subjects with over 5-year natural menopause and decreased bone mineral density (BMD) were randomized into two groups: treatment group in which 102 cases were given oral 'Qianggu Extracts', 20 ml each time and three times daily for 6 months, and control group in which 36 cases were treated with calcium gluconate, 500 mg each and twice a day for 6 months. The BMD and bone metabolism in neck of femur was assayed. Results: In treatment group, the bone pain was relieved obviously, the average BMD rose by 5.89%, E 2, ALP and Ca increased, while PYD fell remarkably; the total effective rate was 93.14%, with no side effects. All these were improved more significantly in treatment group than in control group. It is indicated that 'Qianggu Extracts' is effective in preventing PMOP.