血脂异常对血清细胞黏附分子水平的影响

The influence of dyslipidemia on the levels of serum cell adhesion molecules

目的 :探讨血脂异常对血清细胞间黏附分子 1(ICAM 1)、血管细胞黏附分子 1(VCAM 1)和E 选择素水平的影响。方法 :入选 12 0例研究对象 ,其中高胆固醇血症 (Ⅰ组 ) 31例 ;高三酰甘油血症 (Ⅱ组 ) 30例 ;混合性高脂血症 (Ⅲ组 ) 2 9例 ;血脂正常 (Ⅳ组 ) 30例。用酶联免疫吸附法检测血清ICAM 1、VCAM 1和E 选择素水平 ,比较上述 3个指标在各组间的差异。结果 :总胆固醇水平 ,Ⅰ组 [(6 .5 5± 0 .6 7)mmol/L]和Ⅲ组 [(6 .2 7±0 .6 7)mmol/L]显著高于Ⅳ组 [(4.38± 0 .4 9)mmol/L],P <0 .0 1;三酰甘油水平 ,Ⅱ组 [(3.39± 0 .6 0 )mmol/L]和Ⅲ组 [(3.4 4± 0 .6 2 )mmol/L]显著高于Ⅳ组 [(1.39± 0 .4 0 )mmol/L],P <0 .0 1。同时 ,血清ICAM 1水平在Ⅰ组 [(76 4± 71) μg/L]、Ⅱ组 [(74 9± 71) μg/L]和Ⅲ组 [(82 3± 80 ) μg/L]明显高于Ⅳ组 [(6 0 4± 6 7) μg/L],P <0 .0 1;血清VCAM 1水平在Ⅰ组 [(1837± 16 4 ) μg/L]、Ⅱ组 [(1836± 16 0 ) μg/L]和Ⅲ组 [(196 3± 181) μg/L]明显高于Ⅳ组 [(130 7± 14 9) μg/L],P <0 .0 1;血清E 选择素水平在Ⅰ组 [(6 6± 12 ) μg/L]、Ⅱ组 [(70± 14 ) μg/L]和Ⅲ组 [(81± 17) μg/L]明显高于Ⅳ组 [(39± 11) μg/L],P <0 .0 1。结论

Objective:To discuss the influence of dyslipidemia on the levels of serum intercellular adhesion molecule 1(ICAM 1), vascular adhesion molecule 1 (VCAM 1) and E selectin.Methods:We measured the levels of serum ICAM 1, VCAM 1 and E selectin by ELISA among 120 cases, including 31 cases with hypercholesterolemia(groupⅠ), 30 cases with hypertriglyceridemia(groupⅡ), 29 cases with mixed hyperlipidemia(groupⅢ) and 30 cases without dyslipidemia(groupⅣ). We compared with the levels of three markers between four groups.Results:The levels of total cholesterol in groupⅠ[( 6.55 ± 0.67 ) mmol/L] and in groupⅢ[( 6.27 ± 0.67 ) mmol/L] were much higher than in that groupⅣ[( 4.38 ± 0.49 ) mmol/L], P< 0.01 . The levels of triglyceride in groupⅡ[( 3.39 ± 0.60 ) mmol/L] and in groupⅢ[( 3.44 ± 0.62 ) mmol/L] were much higher than that in groupⅣ[( 1.39 ± 0.40 ) mmol/L], P< 0.01 . Meanwhile, Serum ICAM 1 levels were significantly higher in groupⅠ[( 764 ± 71 ) μg/L], groupⅡ[( 749 ± 71 ) μg/L] and groupⅢ[( 823 ± 80 ) μg/L] than that in groupⅣ[( 604 ± 67 ) μg/L], P< 0.01 ; Serum VCAM 1 levels were significantly higher in groupⅠ[( 1 837 ± 164 ) μg/L], groupⅡ[( 1 836 ± 160 ) μg/L] and groupⅢ[( 1 963 ± 181 ) μg/L] than that in groupⅣ[( 1 307 ± 149 ) μg/L], P< 0.01 ; Serum E selectin levels were significantly higher in groupⅠ[( 66 ± 12 ) μg/L], groupⅡ[( 70 ± 14 ) μg/L] and groupⅢ[( 81 ± 17 ) μg/L] than that in groupⅣ[( 39 ± 11 ) μg/L],P< 0.01 .Conclusion:Dyslipidemia may raise the levels of serum ICAM 1, VCAM 1 and E selectin.