1,1′-二烷基-乙酰基二茂铁的反相色谱研究

A Study on Reversed Phase Chromatography of 1,1′-Dialkylacetylferrocenes

以甲醇-[乙酸-水(2%,V/V)]为流动相,用RP-TLC确定了1,1′-二烷基-乙酰基二茂铁RP-HPLC的分离条件.两系列同系物的RM、lgk′分别与两个茂环上烷基碳原子数及流动相中甲醇的含量成线性关系;在同类异构体中,对于相同碳数的烷基,支链烷基取代物的保留值小于直链烷基取代物;当两个茂环上烷基相同,取代位置不同时,β-异构体的保留值小于α-异构体,表明β-异构体比α-异构体极性大.

The separation conditions of RPHPLC for 1,1′dialkylacetylferrocenes were determined by means of RPTLC using methyl alcohol[acetic acidwater (2%, V/V)] as mobile phase. The linear relationships were found between the values of the RM,lgK′ of two series homolgs and the carbon number of substituted alkyl on the two Cp rings, and between the RM,lgK′ and the fraction of methyl alcohol in the mobile phase.When the carbon numbers of alkyl and substituted position on the two Cp rings were same,the retention values of branch chain alkyl isomers were lesser than that of straight chain.When alkyls on the two Cp rings was same,but substituted position was different,the retention values of βisomers were lesser than that of αisomers.It showed the polarity of the βisomers is stronger than that of αisomers.