痹痛消颗粒治疗腰椎间盘突出症(LDP)的实验研究

Experimental Study of Bitongxiao Granules in the Treatment of Prolapse of Lumbar Intervertebral Disc

目的 :研究痹痛消治疗腰椎间盘作用的机制。方法 :将小鼠分为生理盐水组、阿司匹林组、痹痛消低、中、高剂量组 ,观察痹痛消的镇痛作用和对小鼠耳廓肿胀的影响 ;将大鼠分为生理盐水组、阿司匹林组、痹痛消中高剂量组 ,观察痹痛消对大鼠足跖肿胀的影响 ;将大鼠分为正常对照组、空白对照组、阿司匹林组、痹痛消颗粒组 ,在不同时间观察痹痛消对化学性神经根炎模型的影响。结果 :痹痛消镇痛明显 ,能抑制小鼠耳廓肿胀和大鼠足跖肿胀 ,作用持久显著 ,可抑制化学性神经根炎模型大鼠炎性肉芽肿的形成 ,降低模型大鼠的全血粘度、血浆粘度、红细胞聚积指数。结论 :痹痛消颗粒是通过抗炎、镇痛。

Objective: To study Bitongxiao’s mechanism of action. Method: Divide mouse into normal saline group, aspirin group, Bitongxiao small dose, medium dose, and large dose groups to observe Bitongxiao’s analgesic action and effect on auricular swelling. Divide rats into normal saline group, aspirin group, Bitongxiao medium and large dose group to observe Bitongxiao’s effect on swelling of toes. Divide rats into normal control group, blank control group, aspirin group, and Bitongxiao group to observe at different times Bitongxiao’s effect on chemical radiculoneuritis in duplicated models. Results: Bitongxiao has an analgesic action, and can inhibit mouse’s auricular swelling and rat’s swelling of toes continuously for a long time. It can also prevent inflammatory granuloma in rats with chemical radiculoneuritis, reduce whole blood viscosity, plasma viscocity, RBC aggregation. Conclusions: Bitongxiao granules work on prolapse of lumbar intervertebral disc because of the anti-inflammatory and analgesic action and its ability to improve blood circulation.