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KCNE基因家族与长QT综合征

KCNE Gene Family and Long QT Syndrome
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摘要 KCNE基因家族是一组基因结构上相似,编码产物结构功能相近的一组基因,它们的蛋白产物被称作Mink相关肽(mink-related peptides MiRPs),是构成电压门控钾通道的辅助亚单位-β亚单位,与相应的钾通道的α亚单位相互作用形成稳定具有特定功能的复合体-完整的钾通道.
作者 裴艳 徐文渊
出处 《同济大学学报(医学版)》 CAS 2003年第4期353-355,359,共4页 Journal of Tongji University(Medical Science)
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参考文献16

  • 1Tinel N, Diochot S, Borsotto M, et al. KCNE2 confers background current characteristics to the cardiac KCNQ1 potassium channel[J]. EMBO J, 2000, 19(23): 6326 - 6330.
  • 2Zhang M, Jiang M, Tseng GN. minK-related peptide 1 associates with Kv4.2 and modulates its gating function:potential role as beta subunit of cardiac transient outward channel? [J]. Circ Res, 2001,88 (10) : 1012 - 1019.
  • 3Abbott GW,Sesti F,Splawski I ,et al. MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia[ J ]. Cell, 1999,97(2) : 175 - 187.
  • 4Abbott GW, Butler MH, Bendahhou S, et al. MiRP2 forms potassium channels in skeletal muscle with Kv3.4 and is associated with periodic paralysis[J]. Cell, 2001, 104(2) :217 - 231.
  • 5Sanguinetti MC, Curran ME, Zou A, et al. Coaasembly of KVLQT1 and Mink (Iks) proteins to form cardiac Iks potassium channel[ J ]. Nature, 1996,384 (6604) : 80- 83.
  • 6McDonald TV, Yu Z, Ming Z, et al. A Mink - HERG complex regulates the cardiac potassium current IKr[J]. Nature, 1997,388 (6639) : 289 - 292.
  • 7Splawski I ,Tristani M, Lehmann MH, et al. Mutations in the hminK gene cause long QT syndrome and suppress IKs function[J]. Nat Genet, 1997,17(3) :338 -340.
  • 8Pusch M, Magrassi R, Wollnik B, et al. Activation and inactivation of homomeric KVLQT1 potassium channels [J]. Biophys, 1998,75(2) :785 - 792.
  • 9Sesti F, Goldstein SAN. Single channel characteristics of wildtype Iks channels and channels formed with two mink mutants that cause long QT syndrome[J]. J Gen Phys, 1998,112(6) : 651 - 664.
  • 10Splawski I, Shen J, Timothy KW, et al. Spectrum of mutations in long-QT syndrome genes. KVLQT1, HERG, SCN5A, KCNE1 and KCNE2 [ J ]. Circulation, 2000,102(10) :1178- 1185.

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