慢性酒精中毒性精神障碍患者血清sIL-2R的测定

Detection of serum soluble interleukin 2 receptor in patients with chronic alcoholism

目的 探讨慢性酒精中毒性精神障碍患者血清中可溶性白细胞介素 2受体 (sIL 2R)水平的变化及其意义。方法 用双抗夹心ELISA法对 32例慢性酒精中毒性精神障碍患者和 30例健康对照血清中sIL 2R水平进行测定。结果 慢性酒精中毒性精神障碍患者血清中sIL 2R水平 (438.75± 92 .5 4 μ/ml)高于对照组 (2 73.6 7± 4 9.4 3μ/ml) (P <0 .0 0 1) ,两组个体间有部分重叠。结论 慢性酒精中毒性精神障碍患者血清sIL 2R水平增高表明有免疫功能抑制。

Objective To study the level of serum soluble interleukin 2 receptor in patients with chronic alcoholism and its clinical significance. Methods The level of serum sIL-2R was detected in 32 patients with chronic alcoholism and 30 healthy control with monoclonal and polyclonal antibody sandwich-ELISA. Results Serum sIL-2R was significantly higher in the group of patients than in the control (438.75±92.54μ/ml vs. 273.67±49.43μ/ml, P <0.001). There was some overlapping of sIL-2R value between the patients group and control group. Conclusions The patients with chronic alcoholism present a significant increase of serum sIL-2R and an inhibition of immunological function.