维持性血液透析及肾移植患者乙型及丙型肝炎病毒感染调查

The Status of Hepatitis B and Virus Infection in Patients Receiving Maintenance Hemodialysis after Kidney Transplantation

目的 了解维持性血液透析及肾移植患者乙型及丙型肝炎病毒感染状况。方法 采用 EL ISA及 PCR法测定 HBVm、抗 - HCV、HCV RNA,型特异性 HCV亚基因探针杂交分型。结果 长期血透者 HCV阳性率为37.2 4 % ,肾移植术后再透析者达 4 7.5 7% ,且与透析时间、输血次数、受血量正相关 ;HCV基因型以混合型为主 ,占 6 3.6 4 %。结论 本组患者 HBV、HCV感染率与输血次数、输血量及透析时间密切相关。

OBJECTIVE To investigate the relationship between HBV and HCV infections in patients receiving maintenance hemodialysis and kidney transplantation. METHODS HBVm, anti HCV, HCV RNA and HCV genotypes were detected using ELISA, RT PCR and Southern blot hybridization methods. RESULTS The positive rate of anti HCV was 37.24% in all 196 cases and 47.57% in 38 patients receiving rehemodialysis after kidney transplantation and positively correlated with the duration and times of hemodialysis and volume of transfusion. Mixed genotypes accounted for 63.64% in all the patients. CONCLUSIONS HBV and HCV infection rates are closely related to the times and volume of transfusion and the period of hemodialysis.