11例嗜麦芽寡养单胞菌医院感染临床分析

Nosocomial Stenotrophomonas maltophilia Infection: A Clinical Analysis of 11 Cases

目的 探讨嗜麦芽寡养单胞菌所致医院感染的临床易感因素及防治措施。方法 对我院 11例嗜麦芽寡养单胞菌医院感染的病例进行回顾性调查分析。结果 11例嗜麦芽寡养单胞菌感染患者中 ,老年、住 ICU且伴有糖尿病和(或 )慢性阻塞性肺病 (COPD)等基础病者占多数 ,住院天数较长 ,以下呼吸道感染为主 ,患者在嗜麦芽寡养单胞菌感染发生前均使用了抗菌药物 ,嗜麦芽寡养单胞菌对甲氧苄啶 /磺胺甲 唑耐药例数最少。结论 使用呼吸机及强效广谱抗菌药物的大量应用是发生嗜麦芽寡养单胞菌感染的重要危险因素 ,治疗上可考虑选择甲氧苄啶

OBJECTIVE To study the risk factors, prevention and treatment in patients with Stenotrophomonas maltophilia infection. METHODS A retrospective investigation was done in 11 cases. RESULTS Most of the cases were aged and in ICU, and suffered from such underlying diseases as diabetes mellitus and/or chronic obstructive pulmonary disease. The hospital stay was all over 30 days. Lower respiratory tract infection was in the majority. All the patients received antibacterial agents prior to S. maltophilia infection occurring. The isolates resistant to TMP/SMZ were few. CONCLUSIONS The use of ventilator and broad spectrum antibacterial agents might be the two main predisposing factors of S. maltophilia infection. TMP/SMZ may be the drug of choice for treatment.