降纤酶治疗糖尿病周围神经病变18例临床观察

Clinical Observation of 18 cases of diabetic pheriphral neuropathy Treating with Defibrase

目的 探讨应用蛇毒降纤酶治疗糖尿病性周围神经病变的可行性。 方法 选择 2型糖尿病并糖尿病周围神经病变患者 1 8例 ,给予降纤酶 5 u加入生理盐水 2 5 0 ml中静脉滴注 ,隔日 1次 ,7次为 1疗程 ,共 3个疗程。测定治疗前后空腹血糖 (FPG)、餐后 2 h血糖 (2 HPG)、尿素氮 (BUN)、红细胞压积(HCT)、血小板 (PLT)等 ,进行临床症状及体征评分 ,测定四肢运动及感觉传导速度。 结果 1 8例患者凝血酶原时间和活动度均有所下降 ,无 1例有出血倾向 ;治疗后 FPG、 2 HPG和 PLT较治疗前明显降低 ;治疗后腓总神经、胫神经 MCV比治疗前增高。 结论 降纤酶对糖尿病神经病变有一定的治疗作用 。

Objective To study the feasibility of defibrase in treating diabetic peripheral neuropathy Methods All of 18 the patients with diabetic mellitus (Ⅱ)and diabetic peripheral neuropathy were given 5u defibrase in 250 NS every other day intravenously for 21 times FPG 2HPG BUN HCT and Plt were measured before and after treatment Moter conductive velocity(MCV) and sensory conductive velocity (SCV) of limbs were detected also Result The PT of all patients decreased ,but no patient bleed; FPG 2HPG and Plt decreased after treatment; MCV of tibial nerve and fibulial nerve increased Conclusion It was effective of defibrase in treating diabetic peripheral neuropathy , but the mechanism should be detected continuously