摘要
目的 研究红花黄素对心肌缺血 -再灌注大鼠的影响。方法 建立大鼠冠脉结扎致心肌缺血 -再灌注损伤模型 ,观察红花黄素预防性给药对缺血大鼠血浆中肌酸磷酸激酶 (CPK)、乳酸脱氢酶 (LDH)活性及心肌和血浆中脂质过氧化物丙二醛 (MDA)含量 ,超氧化物歧化酶 (SOD)活性的影响。结果 红花黄素预防性给药能明显降低血浆CPK、LDH的活性及MDA含量 ,提高SOD的活性 ,具有明显的抗氧化性。结论 红花黄素对实验性心肌缺血 -再灌注大鼠具有明显的保护作用 。
AIM The preventive effects of safflor yefflor (SY) on myocardium injury of myocardium ischemic reperfusion (I/R) was studied. METHODS The contents of MDA activity of SOD,as well as the activity of creatine phospho kinase(CK) and lactate dehydrogenase(LDH) were determined in rat models injured by I/R. RESULTS SY could reduce the activities of CK and LDH ,decrease the the content of MDA in plasmo, and increase the activities of SOD. CONCLUSION SY may obviously prevent the rat I/R model which may be related to its anti lipoperoxidation.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2003年第9期1032-1034,共3页
Chinese Pharmacological Bulletin
基金
安徽省重点科研项目资金资助课题 No 0 10 41183
关键词
红花黄素
缺血-再灌注
脂质过氧化
safflor yellow
ischemia reperfusion
anti lipoperoxidation
