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重组寄生虫-St疫苗研究进展 被引量:1

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摘要 鼠伤寒沙门氏杆菌(Salmonella typhimurium,S.t)减毒株主要用于伤寒和副伤寒的免疫防治.分子生物学技术的发展为将St减毒株发展成为多价疫苗载体打下了坚实的基础.人们利用基因突变构建了许多St减毒株,通过染色体整合系统和平衡致死载体-宿主系统等途径可将外源DNA有效引入St减毒株,从而使St减毒株稳定表达外源基因.本文拟就St减毒株构建和St疫苗构建及其作用机制进行综述.
出处 《地方病通报》 2003年第3期103-106,共4页 Endemic Diseases Bulletin
关键词 寄生虫 疫苗 综述
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