摘要
综述了乳化溶剂挥发法、相分离法、喷雾干燥法及溶融法等以聚乳酸(PLA)及其以共聚物为基材制备药物微球的方法,讨论了上述诸法制备过程中影响微粒特征的因素、微球降解以及药物释放的机理,最后展望了聚乳酸及其共聚物在药物缓释、控释方面的应用前景。
This paper reviews the preparation ways of microspheres based on polylactide and its copolymer, such as emulsion evaporation, phase seperation, spray drying and molten method. The effect on the characters of microspheres, the mechanism of the degadation of microspheres and the release of drug are discussed. Finally the applications of polylactide and its copolymer in sustained and controlled drug release delivery system are also prospected.
出处
《同济大学学报(自然科学版)》
EI
CAS
CSCD
北大核心
2003年第9期1054-1058,共5页
Journal of Tongji University:Natural Science
基金
上海市科学技术发展基金资助项目(002312024)
上海市重点基础研究资助项目(02DJ 14601)
关键词
聚乳酸及其共聚物
微球
缓释
降解
polylactide and its copolymer
microsphere
sustained release
degradation