聚乳酸及其共聚物在缓释药物中的研究及应用

Research and Applications on Polylactide and Its Copolymers in Drug Delayed Release System

综述了乳化溶剂挥发法、相分离法、喷雾干燥法及溶融法等以聚乳酸(PLA)及其以共聚物为基材制备药物微球的方法,讨论了上述诸法制备过程中影响微粒特征的因素、微球降解以及药物释放的机理,最后展望了聚乳酸及其共聚物在药物缓释、控释方面的应用前景。

This paper reviews the preparation ways of microspheres based on polylactide and its copolymer, such as emulsion evaporation, phase seperation, spray drying and molten method. The effect on the characters of microspheres, the mechanism of the degadation of microspheres and the release of drug are discussed. Finally the applications of polylactide and its copolymer in sustained and controlled drug release delivery system are also prospected.