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SR蛋白研究进展 被引量：8

Progress of the research on SR protein
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摘要 在真核生物众多拼接因子中 ,SR蛋白家族是一类重要的成员 ,它们与一些特定的RNA序列结合 ,帮助识别并选择正确的 5′及 3′拼接位点 ,与其它的拼接因子共同完成拼接任务 ,在决定组织细胞的特异性及个体发育的阶段性方面发挥着关键作用。本文就近 10年来有关SR蛋白的结构和功能的研究进展作一综述。 Among the splicing factors of eukaryon,SR protein family is very important.They are bound to some specific RNA sequences and help to recognize and select correct 5′ and 3′ splice sites,interacting with other splicing factors to finish the work.SR proteins play an important role in determination of the specificity of tissue cells and definition of the stages of individual development.
作者 王善治 袁榴娣
机构地区 东南大学遗传学研究中心遗传与发育生物学系
出处 《东南大学学报（医学版）》 CAS 2003年第4期279-281,286,共4页 Journal of Southeast University(Medical Science Edition)
基金 ~~
关键词 SR蛋白 研究进展 RNA 序列结合 真核生物 分子组成 RNA-binding proteins,SR protein RNA splicing review literature
分类号 Q522.2 [生物学—生物化学] Q756 [生物学—分子生物学]
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参考文献14

  • 1CHANDLER S D,MAYEDA A,YEAKLEY J M, et al.RNA splicing specificity determined by the coordinated action of RNA recognition motif in SR protein[J]. Proc Nail Acad Sci USA, 1997,94(8) : 3596-3601.
  • 2MISTELI T, CACEBES J F,CLEMENT J Q,et al. Serine phoshorylation of SR protein is required for their recruitment to sites of transcription in vivo[J].J Cell Bio1,1998,143(2) :297-307.
  • 3YEAKLEY J M, TRONCHERE H,OLESEN J,et al.Phosphorlation regulates in vivo interaction and molecular targeting of serine/argininerich pre-mRNA splicing factors[J].J Cell Biol,1999,145(3):447-455.
  • 4TACKE R,CHEN Y, MANLEY J L. Sequence-specifc RNA binding by an SR protein required RS domain phosphorylation: creation of an SRp40-specific splicing enhancers[J] .Proc Natl Acad Sci USA,1997,94(4) : 1148-1153.
  • 5ZHU J, KRAINER A R. pre-mRNA splicing in the alsence of an SR protein RS domain[J]. Genes Dev,2000,14(24) : 3166-3178.
  • 6ELDRIDGE A G, LI Y, SHARP P A. The SRml60/300 splicing coactivator is required for exon-enhancer function[J] .Proc Nail Acad Sci USA, 1999,96(11) :6125-6130.
  • 7KANOPKA A, MUHIFMANN O,AKUSJARVI G. Inhibition by SR proteins of splicing of a regulated adenovirus pre-mRNA[J]. Nature, 1996,381(6582) : 535-538.
  • 8FU X D, MANIATIS T. The 35-KDa mammalian splicing factor SC35 mediates specific interactions between U1 and U2 small nuclear ribonucleuoprotein particles at the 3' splice site[J] .Proc Natl Acad Sci USA, 1992,89(5) : 1725-1729.
  • 9JUMMA H,WEI G, NIELSEN P J. BLastocyst formation is blocked in mouse embryo lacking the splicing factor SRp20[J]. Curt Biol,1999,9(16) :899-902.
  • 10LONGMAN D,JOHNSIDNE I L, CACERES J F. Functional characterization of SR and SR-related genes in Caenorhabditis elegans[J]. EMBO J,2000,19(7) : 1625-1637.

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东南大学学报（医学版）
2003年 第4期

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