摘要
目的 :观察前列腺素E1在治疗不稳定性心绞痛中的疗效和副作用。方法 :将 2 82例患者随机分为 2组 ,分别用前列腺素E1和单硝酸异山梨酯治疗 ,观察两组病例用药后的有效率、停药后的复发率及用药前后血小板积聚率的变化。结果 :两组病例治疗的总有效率分别为 97 16 %、94 16 % ,无显著差异 (P >0 0 5 ) ,停药后 2周复发率分别为 3 0 2 %、 2 9% ,治疗组显著低于对照组(P <0 0 1) ,且前者可能显著降低不稳定性心绞痛患者的血小板积聚率 ,发挥抗凝作用。结论 :前列腺素E1兼有扩血管、抗凝双重作用 ,对治疗不稳定性心绞痛疗效肯定、副作用少。
Objective:To observe clinical effects and safety of PGE 1 in patients with unstable angina pectoris Methods: 282 patients with USAP were randomly be divided into two groups: PGE 1 as treatment group including 141 patients, one-isosorbide dinitrate as control group in other patients The effective rates, relapse rates after treatment and the changes of platelet aggregation rate were observed in two groups Result: The total effective rates of treatment group and control group were 97 16% and 94 16% respectively, the differences of effects between the two groups did not exit The relapse rates of two weeks after treatment were 3 02% and 29% respectively, they were different remarkably The platelet aggregation rates in treatment group were decreased obviously and no significant changes wre found in control group Conclusion: PGE 1 had vasodilative and anticoagulant roles, could be used for treating unstable angina pectoris effectively
