联合检测尿微量白蛋白及尿酶对高血压病早期肾损害的诊断价值

Significance of combined urinary microalbumin and urinary enzyme for diagnosis of early renal injure in hypertension patients

目的 探讨尿微量白蛋白 (m A)与尿酶联合检测在高血压病早期肾损害中的诊断价值。方法 对 12 0例高血压病患者及 72例正常人的尿 m A、N-乙酰 -β- D-氨基葡萄糖苷酶 (NAG)、β- D-半乳糖苷酶 (GAL )、甘氨酰脯氨酸二肽氨基肽酶(GPDA)进行了联合检测。结果 高血压病患者尿 m A、NAG、GAL、GPDA均较正常对照组显著增高 (P均 <0 .0 1)。单纯检测上述指标中的一项或两项阳性率较低 ,联合检测其中三项阳性率较高 ,联合检测四项阳性率可达 6 3.3%。 m A与 NAG、GAL、GPDA呈显著正相关 (P<0 .0 1)。结论 提示联合检测尿 m A、NAG、GAL、GPDA是诊断高血压病早期肾损害的敏感指标 ,具有良好的临床应用价值。

Objective To study the role of combined urinary microalbumin and urinary enzyme for diagnosis of early renal injury in hypertension patients.Methods Urinary microalbumin(mA), N-acetyl-β-D-glucosaminidase(NAG), β-D-galactosidase(GAL) and glycyl proline dipeptidyl aminopeptidase(GPDA) were measured in 120 hypertension patients and 72 healthy subjects. The levels of urinary mA, NAG, GAL and GPDA in hypertension patients were significantly higher than those in controls (P<0.001).Results Positive rates of meas-uring one or two of the four markers were lower than that of measuring the four markers together.Measu-ring four markers together would raise the positive rate to 63.3% in hypertension patients. A significant positive correlation was noted between mA and NAG, GAL, GPDA.Conclusion The method is sensitive and of clinical value of application to measure the four markers together in the diagnosis of early renal injury in hypertension patients.