鹿茸精对青年及老年小鼠的生化药理作用

Biochemical Pharmacological Effects of Lurongjing on Young or Old Mice

目的 :研究鹿茸精对青年及老年小鼠的药理作用。方法 :测定鹿茸精对小鼠MAO活性、单胺类递质含量、RNA和蛋白质合成、SOD活性及MDA含量的影响。结果 :鹿茸精可明显抑制老年小鼠脑和肝MAO B活性 ,增加脑 5 HT、DA含量 ,促进RNA和蛋白质合成 ,增强SOD活性 ,降低MDA含量 ,作用明显强于青年小鼠。结论 :鹿茸精对老年小鼠具有一定的抗衰老作用。

Objective: To investigate the effect of Lurongjing (LRJ) on young or old mice Methods: In vivo monoamine oxidase(MAO) and superoxide dismutase(SOD) activities, the contents of monoamines(5 HT,NE,DA), malondialdehyde(MDA), RNA and protein, and the incorporations of Uridine into RNA and Leucine into protein in liver tissue were measured Results: The inhibition of MAO B activity and the increase of monoamines(5 HT, DA) level, the increase of RNA and protein level, and the incorporations of Uridine into RNA and Leucine into protein in liver tissue, the enhancement of SOD activity and the decrease of MDA content in brain and liver tissues were selectively observed in old mice(24 months) than in young mice(1 month) by LRJ (ig, 4 0 g/kg) administrated orally for 10 successive days Conclusion: LRJ exhibits some anti aging effect in old mice