摘要
目的 :探索沙棘油支持大剂量化疗 ,重建化疗后造血功能的可能性。方法 :观察沙棘油灌胃前后小鼠血细胞数值的变化以及沙棘油重建化疗后造血功能障碍动物模型造血功能的作用。结果 :沙棘油灌胃后DBA/ 2小鼠红细胞数升高较明显 ;SCID小鼠灌服沙棘油后红细胞及白细胞数均较灌胃前有明显升高 ,但血小板数无明显变化 ;用沙棘油灌胃治疗化疗后造血功能障碍动物模型 ,第 8天后血细胞数高于阴性对照组 ,死亡率减少。结论 :沙棘油能促进红细胞系造血 ,并与G CSF一样具有促进化疗后骨髓造血功能恢复的作用。
Objective: To investigate the possibility of the oil from Hippophae rhamnoides (OHR) in supporting the hematopoitic reconstitution after high dose chemotherapy Method: The mice were fed with OHR and variation of blood cell counts of the mice was recorded Animal models of myelosuppression were built by 5 Fu intra peritoneal infusion The effects of OHR in the hematopoietic reconstitution were observed Results: The counts of erythrocytes of OHR group were significantly elevated The blood cell counts in myelosuppression mice fed with OHR exceeded those in control group, and the mortality was decreased Conclusion: OHR can improve the hematopoiesis of erythroid linage Like G CSF, OHR can stimulate the recovery of hematopoiesis after chemotherapy
出处
《中药材》
CAS
CSCD
北大核心
2003年第8期572-575,共4页
Journal of Chinese Medicinal Materials
基金
广东省科技厅
卫生厅社会发展协作攻关项目( 2 0 0 2B3 0 2 0 2 )
广州市科技局基金项目 ( 2 0 0 1 Z 0 43 0 1 8)
关键词
沙棘油
造血功能重建
实验研究
化疗
Hippophae rhamnoides
Chemotherapy
Hematopoitic reconstitution
