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Rho GTP酶在内皮细胞通透性增高中的作用 被引量：4

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摘要 在真核细胞中 ,肌动蛋白细胞骨架介导许多重要的生物学功能 ,与细胞的分裂、运动、黏附密切相关。RhoGTP酶家族是细胞信号转导通路中一种重要蛋白 ,它参与调控肌动蛋白细胞骨架的形态改变。近年来RhoGTP酶与细胞骨架蛋白调节方面的研究进展提示 :RhoGTP酶可能在介导细胞因子和炎症介质引致内皮细胞(endothelialcell,EC)通透性增高的过程中起着主要的信号传导作用。
作者 张效林 韩雅玲 康建
机构地区 沈阳军区总医院全军心血管内外科研究所心内科
出处 《国外医学（呼吸系统分册）》 2003年第4期201-203,共3页 Section of Respiratory System Foreign Medical Sciences
关键词 RhoGTP酶 内皮细胞 通透性 细胞因子 信号传导
分类号 R363 [医药卫生—病理学]
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参考文献19

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同被引文献58

  • 1张曼,屈晨,曾定尹.Rho/Rho激酶在压力负荷心力衰竭大鼠心肌组织的表达[J].中华心血管病杂志,2005,33(1):73-76. 被引量：52
  • 2曹源,舒晓春,吴贻全,刘铭.复方丹参对冠心病基质金属蛋白酶-9和肿瘤坏死因子-α的影响[J].心血管康复医学杂志,2005,14(4):319-321. 被引量：12
  • 3马小欣,赵慧颖,徐宝华.Rho/Rho激酶与动脉粥样硬化及冠心病的关系[J].中国微循环,2007,11(2):138-141. 被引量：9
  • 4Nakayama M, Amano M. Rho-kinase and myosin Ⅱ activities are required for cell type and environment specific migration[ J]. Genes to Cells,2005,10 (2) : 107 - 117.
  • 5Eaton R, Su C, Valencia T, et al. Transforming growth factor-β1- induced expression of smooth muscle marker genes involves activation of PKN and p38 MAPK[ J ]. Journal of Biological Chemistry,2005, 280(35) :31172 -31181.
  • 6Shimokawa H, Morishige K, Miyata K, et al. Long-term inhibition of Rho,kinase induces a regression of arteriosclerotic coronary lesions in a porcine model in vivo[ J]. Cardiovasc Res, 2001,51 ( 1 ) : 169 - 177.
  • 7Weihua N, Shiro K, Minako I, et al. Monoeyte Chemoattraetant Protein-1 Is an Essential Inflammatory Mediator in Angiotensin Ⅱ-Induced Progression of Established Atherosclerosis in Hypercholesterolemic Mice. Arteriosclerosis, Thrombosis, and Vascular Biology [ J ]. Arterioscler Thromb Vasc Biol,2004 ,24 :534 - 539.
  • 8Pawlak G, Helfman DM. Regulation of Ras-related RhoB protein expression during the cell cycle [ J]. Current Opinion Genetics Development,2001, 11:141 - 147.
  • 9Shimokawa H, Takeshita A. Rho-Kinase Is an Important Therapeutic Target in Cardiovascular Medicine[J]. ArterioscIer Thromb Vasc Biol, 2005,25(9) :1757 - 1775.
  • 10Masao T, Jianxin S, Junko H, et al. Rho-kinase mediates hypoxia-induced downregulation of endothelial nitric oxide synthase[ J]. Circulation,2002, 106:57 - 62.

引证文献4

二级引证文献16

国外医学（呼吸系统分册）
2003年 第4期

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