甲亢患者IL-4、IL-10水平检测的临床意义

Clinical Significance of Changes of Serum IL-4 and IL-10 Levels in Patients with Graves’ Disease

目的 :探讨IL - 4、IL - 10水平变化在甲亢的临床意义。方法 :选择甲亢未治疗组 6 4例、甲亢经1 31 I治疗组 39例和正常对照组 35例 ,用化学发光法测定FT3、FT4 、TSH的含量 ,用放射免疫分析测定IL - 4、IL - 10含量。结果 :甲亢未治疗组患者血清IL - 4、IL - 10水平均高于正常对照组 (p <0 0 1、p <0 0 5 )。1 31 I治疗组患者血清IL - 4、IL - 10水平均低于未治疗组 (p <0 0 1、p <0 0 5 )。甲亢1 31 I治疗组患者血清IL - 4、IL - 10与正常对照组差异无显著性 (p>0 0 5 )。结论 :IL - 4、IL - 10在甲亢的发病机理中起重要作用 ,判断疗效有一定意义。

Objective To explore the clinical significance of changes of serum IL-4 and IL-10 in patients with Graves' Disease. Methods Serum thyroid bormones (FT 3, FT 4, TSH, with chemiluminescence method) and cytokines (IL-4, IL-10 with RIA) levels were measured in 138 individuals, consisting of 64 patients with untreated Graves' disease, 39 patients with Graves' disease treated with 131 I and 35 controls. Results Serum IL-4 and IL-10 levels in patients before treatment were significantly higher than those in controls ( p<0 01, p<0 05 respectively). After successful treatment, the levels dropped, being significantly lower than those before treatment ( p<0 01,p <0 05) and not much different from those in controls ( p >0 05). Conclusion IL-4 and IL-10 played impontant role in the development of Graves' diseace. Returning from high serum levels towards normal reflected the treatment effectiveness.