川芎嗪治疗老年消化性溃疡的研究

Study of ligustrazine on peptic ulcer in senile patients

目的 探讨川芎嗪治疗老年消化性溃疡的疗效和机制。方法 将 70例老年消化性溃疡患者随机分成川芎嗪组 (35例 )和对照组 (35例 )。对照组口服硫糖铝 1.0g 3次 /d ,雷尼替丁 15 0mg 2次 /d ;川芎嗪组在对照组药物的基础上 ,加用川芎嗪注射液 16 0mg静脉点滴 1次 /d。两组均治疗 4周 ,观察胃镜及临床疗效 ,并在治疗前后测血浆丙二醛 (MDA)、红细胞膜超氧化物歧化酶 (SOD)及血液流变学指标。结果 腹痛缓解率川芎嗪组为 10 0 % ,对照组为 95 %。溃疡愈合率和幽门螺杆菌 (H .pylori)转阴率川芎嗪组分别为 97.1%和 86 .9% ,对照组分别为 82 .8%和4 5 .5 % ,两组比较差异显著 (P <0 .0 5 )。MDA降低 ,而SOD明显升高 ,治疗前后及两组比较有显著性差异 (P <0 .0 1或 0 .0 5 )。同时川芎嗪组血液黏滞度下降。

Objective It is to discuss the therapeutic effect and mechanism of ligustrazine on peptic ulcer in senile patients. Methods 70 senile patients with peptic ulcer were divided into ligustrazine group (35 cases) and control group (35 cases) at random. Control group was treated with ulcerlmin 1.0?g per oral three times a day and ranitidinum 150 mg per oral twice a day. On the base of the drugs in the control group, ligustrazine group were treated with ligustrazine injection intravenous dropping once a day. The two groups were both treated four weeks, then the gastroscope and clinical effects were observed. The plasma MDA, superoxide dismutase (SOD) and hemorheology index were examined before and after treatment. Results The bellyache remit rate, ulcer healing rate and H.pylori clearance rate in ligustrazine group were 100%, 97.1% and 82 8%. Those in control group were 95%, 86.9% and 45.5%. There was significant difference between the two groups (P<0 05). MDA lowed and SOD rose obviously. The difference between the two groups and between before and after treatment was significant (P<0.01 or 0.05). At the same time, the hemorheology index descended. Conclusion Ligustrazine can obviously heighten the healing rate of peptic ulcer in senile patients.